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Earlier today I posted the second article in what is turning out to be a short series in the investigation into why the performance of IronPython is around 100× slower than CPython, when running the front-end of my OWL BASIC compiler.
The most informative comment was [...]

IronPython 2.0 can be hundreds of times slower than CPython on some microbenchmarks. Jython 2.5 can scale better than CPython on those same benchmarks.

IronPython can be slow – 10x to 100x slower than CPython on real-world code and it has been observed to be up to 6000x slower.